3348 Structural Determinants of Neoantigen Immunogenicity for Cancer Therapy
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چکیده
منابع مشابه
Personal neoantigen cancer vaccines
Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient's tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens in immune control of cancer. Despite manufacturing complexity, outstanding questions and desired further improvements, neoantigen vaccines are currently undergoing clinic...
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Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder that occurs with variable frequency in patients exposed to heparin. HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, but the biophysical properties of complexes that initiate antibody production are unknown. To identify structural dete...
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چکیده ندارد.
15 صفحه اولNeoantigen: A Long March toward Cancer Immunotherapy.
Somatic mutations in cancer give rise to neoantigens. Technology revolutions in cancer genomics and immunology have made it possible to rapidly identify neoantigens for cancer vaccines. Leisegang and colleagues report that it is practical to rapidly identify neoantigens for adoptive T-cell therapy in a mouse tumor model. Clin Cancer Res; 22(11); 2602-4. ©2016 AACRSee related article by Leisegan...
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In this paper, we have analyzed a mathematical model for the study of interaction between tumor cells and oncolytic viruses. The model is analyzed using stability theory of differential equations. We gain some conditions for global stability of trivial and interior equilibrium point.
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ژورنال
عنوان ژورنال: Journal of Clinical and Translational Science
سال: 2019
ISSN: 2059-8661
DOI: 10.1017/cts.2019.54